In a concerning press release issued by the European Society of Cardiology entitled, “‘HARMLESS’ PAINKILLERS ASSOCIATED WITH INCREASED RISK OF CARDIAC ARREST,”2 researchers warn that painkillers considered harmless by the general public are associated with a significantly increased risk of cardiac arrest.
The report was based on a study entitled, “Non-Steroidal Anti-Inflammatory Drug Use Is Associated With Increased Risk of Out-Of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study,” published in the March issue of European Heart Journal – Cardiovascular Pharmacology.
Professor Gunnar H. Gisalson, one of the lead researchers explained in interview:
Allowing these drugs to be purchased without a prescription, and without any advice or restrictions, sends a message to the public that they must be safe.
Previous studies have shown that NSAIDs are related to increased cardiovascular risk which is a concern because they are widely used.
The study looked at a total of 28,947 patients who experienced an out-of-hospital cardiac arrest in Denmark over the course of a decade. Heart attack differs from cardiac arrest in that the former involves damage to the heart when the blood supply stops (usually through obstruction of circulation), whereas the latter involves damage from the heart itself stopping. 3,376 of these were treated with an non-steroidal anti-inflammatory drug (NSAIDs) up to 30 days before the event. The most common NSAIDs used were ibuprofen (51%) and diclofenac (22%).
The study results revealed that NSAID use was associated with a 31% increased risk of cardiac arrest. Ibuprofen and diclofenac increased the risk by 31% and 50%, respectively. Naproxen, celecoxib and rofecoxib were not associated with increased cardiac arrest.
Gunnar remarked on these findings:
The findings are a stark reminder that NSAIDs are not harmless. Diclofenac and ibuprofen, both commonly used drugs, were associated with significantly increased risk of cardiac arrest. NSAIDs should be used with caution and for a valid indication. They should probably be avoided in patients with cardiovascular disease or many cardiovascular risk factors.
This is not the first time that ibuprofen’s profound cardiotoxicity has come to light. We reported on the subject five years ago in an article entitled, Ibuprofen Kills Thousands Each Year, So What Is The Alternative?
We can work on the pain safely and help address the cause!